I get a message saying please insert original CD. every time i run ToB and the loading screen comes up i move my mouse around all the time this seems to work. hope this helps anyone.

Yeah I get the same problem, it seems to be a problem withe computer not actually reading the cd though as when I click on the cd drive it does not know there is a cd in the drive, I manage to get roung this by restarting the PC with the TOB cd in the drive.

Do you have CD Auto-Insert Notification disabled? I know some CD writing programs such as Nero demand that it be disabled (for what reason I cannot fathom) and I've had problems with other programs that require the CD in the drive, if you put the disc in the drive but Windows isn't notified to the change automatically.