I find that Minsc and Jan are brilliant together, especially when Jan tries to steal Boo. However, in ToB what are the funniest combinations of NPC? Do they all involve Jan?

Imoen - Keldorn banter is precious... Sarevok has the most banters, I would think, but they are not humorous. Except the one with jan, which is hilarious... Count Turnipsome... :D

Yes, I definitely enjoy the Imoen turning Keldorn red-faced banter.

Jaheira having some witty fun at the expense of Edwin(a) not once, but twice, is absolutely priceless.

Watching Jaheira and Viconia fight over you, the dialogue is completely serious, yet so funny just to watch it in motion.

The Imoen-Anomen banter where Imoen subtly calls Anomen on being a prig is quite fun as well.

I've never tried it, but after completing the NPC interactions guide, the Korgan-Mazzy duo is a definite competitor for THE funniest pairing of all.

If Jan and Imoen are in your party she will tell a funny story like he does...

@ Beren

I would agree that without a doubt, the Mazzy-Korgan pairing is the funniest in the game.

Additionally, I think just about any pairing of a few good aligned and evil aligned characters in your party are great. I think the "digs" they give each other are really funny. (Anything with Edwin is usually really funny.) But Mazzy-Korgan gets my vote.

I think that all the NPCs interaction are great, but sadly, you have to wait too much time sometimes, maybe if they interact, let's say, each time when you are just walking around or when you are traveling between areas, or when you get to an area after the load screen. I don't know, just is the way I would like to be.
Sometimes you miss a lot of them beacuse some re-loading game.

I am a big fan of the Jan / Haer'Dalis interactions, for example, when Jan decides to write a poem and asks the Blade for a rhyme for "Bucket". Too funny. Jan is without a doubt my favorite NPC, and that's not just because he gets so powerful my the end of the game.

@Jurts
You did not like the one where Viccy tries to sleep with Sar?

The Mazzy-Valygar banters are funny, as is the banter where Anomen makes a pass at Edwin(a).